Why Disappointment Is Crushing: Dopamine, Addiction and the "Hedonic Treadmill"

Sep 19 2016

Why Disappointment Is Crushing: Dopamine, Addiction and the “Hedonic Treadmill”

Disappointment is one of my least favorite emotions, and I know I’m not alone in my hatred of it. Among people with addiction, dashed hopes are a common trigger for relapse. And even if you’ve never been addicted, it’s quite tempting to respond to an unexpected loss, failure or rejection by having a drink or two.

In fact, the connection between disappointment and addiction is a deep, neurological one—and it’s likely driven by the same critical neurotransmitter: dopamine.

If you’ve heard of dopamine at all—and at this point, what person concerned with addiction hasn’t?—you’ve probably heard it described as a “pleasure” or “reward” chemical. Cartoonish depictions of dopamine as the driver of addiction—with high dopamine signaling euphoria and low dopamine signaling withdrawal—abound. But it’s actually far more complicated—and much more intriguing in a way that is directly linked to the extreme displeasure of disappointment.

To start, dopamine isn’t completely unrelated to pleasure. However, its action in the motivational circuitry of the brain only plays a role in one type of positive experience: the joy of desire.

Here, dopamine rises when we anticipate good things, but not necessarily when we get them. Dopamine pleasures are exciting, motivating, exhilarating—not relaxing, grounding or calming: basically, stimulant highs rather than those from depressants. The pleasures of satisfaction, in fact, are linked, instead, to the brain’s opioids, or heroin-like chemicals. And, as we all know, unsated desire is far from pleasurable.

So what does dopamine have to do with disappointment? Many researchers now think that, when acting in certain circuits, dopamine connects expectations with actual experience—or, in the jargon of science, it signals “reward prediction error.” And what that means is that dopamine rises or falls with the accuracy of our mental projections, which makes an inaccurate prediction of a reward punishing.

A prediction error is mathematically simple: It’s the difference between what you expect and what you get. Research originally conducted by Cambridge University’s Wolfram Schultz has shown that this correlates with dopamine levels in nonhuman primates.

A positive prediction error means that you got more than you’d thought likely—a pleasant surprise. A negative prediction error, however, means that the promised reward was either missing or less than expected.

“Disappointment would be a negative prediction error,” says Schultz, adding that this describes the human psychology of the experience, rather than what he sees in his work, which involves animals.

But monkeys, too, can be let down: Their dopamine levels fall when a light or sound that typically signals a tasty treat or shot of cocaine isn’t followed by the expected reward, and it’s clear from their behavior, at least, that this isn’t pleasant for them.

When there is a negative prediction error—i.e., when your plans go awry or that delicious-looking cake turns out to be bland and dry—dopamine levels fall. When you get exactly what you expect—no better or worse—they stay stable.

Only when there is an unanticipated delight do you get a big boost.

Unfortunately, this system creates what researchers call the “hedonic treadmill,” which means that unless rewards are constantly getting bigger and more exciting, even the best experiences pale over time when repeated.

What was once terrifyingly thrilling eventually becomes routine: If this didn’t happen, our brains couldn’t remain sensitive to novelty—and that’s essential for learning and therefore, for survival.

Those of us who have addiction are all-too-painfully familiar with this phenomenon, which is known as tolerance or habituation. It means that no matter how much we use, it rarely feels like enough. And, this, too, involves dopamine’s role in prediction.

Basically, when an experience is better than you thought it would be, you remember this fact— and that makes your expectations for the next time higher, meaning they are going to be harder to exceed.

So, even if that beach is exactly as beautiful as it was the first time you vacationed there, unless it has somehow gotten even more great, you typically won’t experience the splendor as intensely. Similarly, that rock or shot.

“The thing with the dopamine neurons is [that] you’re not only getting a high when your reward is better than predicted, but your prediction is also running away,” says Schultz. That means that the same reward, compared to a larger prediction, will give a negative prediction error, making it at least a little disappointing. (This is also why expecting perfection or that some event will be “the best day of your life” is a self-undermining recipe for dissatisfaction.)

During addiction, of course, drugs themselves affect dopamine levels—but this doesn’t free us from the hedonic treadmill. In fact, drugs like cocaine and amphetamine that directly increase dopamine levels make it even more vicious.

By artificially raising dopamine levels, stimulants increase the brain’s prediction that the drugs will be good the next time. And this means that—unless you keep upping the dose—the high will almost never be as fabulous as that “first time” so many people recall so fondly. And even if you can somehow afford ever-increasing doses, this tends to escalate craving, while the level of satiation—how much you like the drug when you get it—remains the same.

In other words, you want the drug more and more, even though, because of the negative consequences of addiction, you may actually like it less. If a drug could actually intensify satisfaction itself over time—rather than simply escalating craving—you’d get the strange phenomenon of having to take less and less to achieve the same high, which would be delightful for drug users but not so much for dealers.

Sadly, however, the only effects that seem to increase with ongoing heavy drug use are negative ones like paranoia and craving. Even with opioids, which act directly at the receptors that drive satiation, tolerance still develops.

Read more from The Influence:

The Rehab Industry Needs to Clean Up Its Act. Here’s How.

“To Love Another Person Is to See the Face of God”—Crazy Little Thing Called Limerence

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All of this means that Buddha was right: Suffering is caused by desire and unless you reduce desire, suffering is inevitable. If you don’t expect too much, you won’t be disappointed; low expectations will lower negative prediction errors.

On the other hand, for me at least, expectations and predictions are motivating, and themselves a source of joy: Being without desire can also mean being without the ability to feel pleasure, as in the anhedonia of depression.

There is, however, a spiritual or simply human antidote to disappointment—one popularized by Buddhism, by other faiths and philosophies and indeed by 12-step programs. And that is gratitude.

If you are grateful for what you have—allowing yourself to feel satisfaction for the present no matter what you desire or predict—this can counteract disappointment.

In my life, I’ve often had to lower my expectations, even though, as a basically optimistic person, this cuts against my grain. Perhaps because of my typically-sunny temperament, when I try to avoid expecting too much, I rarely succeed entirely: My dopamine is going to make some sort of prediction, regardless of what I think on the cognitive level. This has meant that I often find myself disappointed by expectations I didn’t know I had.

When I cultivate gratitude, however—and critically, when I’m not depressed, which can obliterate my normal emotions if I don’t take my antidepressants and keep up my social safety net and do things like exercise—almost anything can become delightful.

I know that my addiction could have killed me, that all of the wonderful things I have in my recovery now are not just because I’ve worked hard and tried to do the right thing, but because I’ve had luck and help and frankly, privilege.

Keeping that in mind makes simple pleasures greater than expected: All of what I have and experience now is a bonus; in spiritual terms, grace.

The dopamine dip of disappointment will always get you sometimes—but we are also much more than that.

Maia Szalavitz is a columnist for The Influence. She has written for TimeThe New York TimesScientific American Mind, the Washington Post and many other publications. She has also authored six books, including Help at Any Cost: How the Troubled-Teen Industry Cons Parents and Hurts Kids (Riverhead, 2006). Her latest book is Unbroken Brain: a Revolutionary New Way of Understanding Addiction. Her last column for The Influence was “The Rules Around Opioid Maintenance Would Be Seen as Unconscionable in Any Other Branch of Medicine.” You can follow her on Twitter: @maiasz.

  • As a drug addict and alcoholic, I know exactly what you’re saying about disappointment. It can be crushing. However, sometimes even ‘normies’ feel that way. Not as profoundly, of course – feeling things more deeply is one of the curses of our disorder. But we should not assume that feeling bad means that there is something ‘wrong’ with us. Because 12 Step groups can pathologize this feeling: “I am happy joyous and free – and there is something wrong with you if you feel bad.” In fact you can safely assume such people are miserable.

  • DavidSmith

    I still get far from pleasure from taking drugs than I do from expecting to take them. For instance, when I am waiting for the dealer to turn up, I mainly feel anxiety and frustration. But when he has done the deal, and I take the drugs, I get more pleasure than I got from any of the events between the last ingestion of drug use and the current experience of intoxication. Sex is good too. Um, sure there was something else that gives me pleasure, but can’t remember it offhand.

  • DavidSmith

    And I still get as much fun taking all the drugs I take as I did when I started taking them 20 years ago. Where do you get this tolerance stuff and why do people want it?

    • Drugs are usually more fun the first time around. Maybe you’re the exception. It’s like a joke or a song – eventually you get tired of it. Most people move on. But other people, like me, panic and think “It’s not working for me any more – I must have been addicted!”

      • DavidSmith

        Honestly, I think you and other people who can’t handle drugs are the exception. Most drug users I’ve known (thousands) like drugs as much now (often more) than when they started off – usually because they have now worked out which drugs they like, how much they need to get their optimal high, how they need to ingest each drug, and how often they need to take them. That includes users of cannabis, ecstasy, cocaine, amphetamines, psychedelics and opioids. Most of these people are never seen by drug services and only ever get their views assessed by those rare studies of drug users not known to the authorities.

        • Those people are at great risk of addiction. It can happen at any age. I hope they get help before it’s too late.

          • DavidSmith

            The only thing wrong with having a drug habit is that it is prohibited by law and people are criminalized for it. If you develop problems with using drugs regularly then you get help from treatment agencies etc, but most regular drug users don’t have any problems other than being threatened with or experiencing criminalization. For instance, many if not most people in western countries have caffeine/xanthine habits (eg. use coffee, tea and/or chocolate every day) but virtually no-one has a real problem with that because its legal and socially acceptable. If using drugs every day makes your life better overall (as it does for me and many other people) then its a useful and positive thing, not a bad one. All this prejudice against people who like using drugs regularly is really unnecessary, and just leads to stigmatization and discrimination.

          • Third eye of the Ewe Are Me

            Its a freaking witch hunt. There is not now and never was any good reason to make drugs illegal. This has been shown over and over again and yet: apparently reason does not stop a witch hunt. How do you stop a witch hunt? How are people so hateful?

          • James DuMouchel

            “How are people so hateful?” Here’s how this got started: anti-drug hysteria, aided and abetted by a gullible press, fueled a fear in the general populace such that they allowed themselves to be stripped of Constitutional rights without which no nation can be considered free.

          • James DuMouchel

            David Smith: Right on, Daddy-o!

        • Olmy Olm

          I feel more or less the same, except for a troubling period I went through in the past – but that had more to do with other things than the drugs themselves.

  • SmotheredHope

    Great article! This is exactly one of the hurdles I have been facing in early recovery: keeping my gratitude higher than my expectations. For myself, i really tend to get in my head after having an awesome day. When the next day pans out to be just a “normal day”, I find my mood getting dark fast. I’ve learned a lot of tools to help me be proactive against it but it is still tough. For me what helps the most is meetings and the fellowship, it’s completely changed my life. I have to stay completely plugged in taking it one day at a time or I know I’ll be out there shooting dope again…and it will fing kill me. So yeah, very grateful for today and for sites like this one!

  • Stephen-in-DC

    I am grateful…. that alcoholism and drug addiction only affect about 4% of society. So only 4% of society has ‘dopamine issues’. Thank you God!

    • Katherine Mancuso

      This isn’t true, actually. People with depression, ADHD, schizophrenia, and other mental illnesses typically have reduced ability for their brain to feel the effects of dopamine. Without the brain’s natural “reward” for a job well done, it becomes difficult to focus on tasks. Serotonin is also implicated in all these conditions.

      As a result, it’s often important for people who have these conditions to use various prescription drugs that affect the dopamine and serotonin cycle, so they can function at work and home. Most of the classic antidepressants such as SSRIs are reuptake inhibitors that interfere with the brain’s system of breaking down dopamine and serotonin so the chemicals hang around for longer, but other folks use herbal supplements that produce more of the precursors to dopamine and serotonin, like L-tyrosine or CBD, and still others use stimulants like Ritalin or even coffee which increase the brain’s sensitivity to dopamine and give you a serotonin rush.